Biostatistics & Clinical Development

Precision
Biostatistics for
Smarter Clinical
Development

We partner with biotech and pharmaceutical companies to deliver high-quality statistical design, analysis, and regulatory-ready outputs — efficiently and cost-effectively.

Senior-Led. Regulator-Ready.

FDA
Regulatory-Ready DeliverablesFDA, EMA, and global submission standards met across every engagement
100%
Senior-Level ExpertiseNo junior outsourcing — every project led by experienced biostatisticians
3
Flexible Engagement ModelsProject-based, FTE, or long-term strategic partnership
I–IV
Phase CoverageFull clinical development lifecycle from IND-enabling to NDA submission
FDA Submission Ready
ICH E9 Compliant
CDISC SDTM / ADaM
SAS & R Programming
Adaptive Trial Design
Bayesian Methods
Double Programming Validation
Real-World Evidence
21 CFR Part 11
EMA Submission Ready
FDA Submission Ready
ICH E9 Compliant
CDISC SDTM / ADaM
SAS & R Programming
Adaptive Trial Design
Bayesian Methods
Double Programming Validation
Real-World Evidence
21 CFR Part 11
EMA Submission Ready
Why Choose Us

Built differently
by design.

Unlike large CROs with layered structures, we operate with a lean, expert-led model — ensuring faster turnaround, direct communication, and lower cost without sacrificing quality.

Senior-Level Expertise Only

No junior outsourcing. Every project is led by experienced biostatisticians who bring deep regulatory knowledge directly to your team. You always know who is working on your program.

Regulatory-Ready Deliverables

All outputs are built to meet FDA, EMA, and global submission standards from the start — not retrofitted. We understand what reviewers expect and design every deliverable accordingly.

Flexible Engagement Model

From ad hoc statistical support to full study ownership, our engagement model adapts to your program's stage and budget. Scope exactly what you need — no rigid structures, no minimums.

Cost Efficiency Without Compromise

Our lean structure means less overhead and more value per dollar — without cutting corners on rigor. High-quality biostatistics doesn't have to come with a large-CRO price tag.

Our Capabilities

End-to-end statistical
services.

From first-in-human through NDA submission, we cover the full statistical lifecycle of clinical development.

01

Biostatistics

Rigorous statistical design and analysis across all development phases, with direct senior oversight at every step.

Phase I–IV Design Sample Size SAP Development Adaptive Trials DSMB Support
02

Statistical Programming

eCTD-ready datasets, TLFs, and submission packages built to CDISC standards in SAS, R, or Python.

SDTM / ADaM TLFs SAS R eCTD Packages
03

Regulatory Support

Submission support, ISS/ISE development, and reviewer response assistance to carry your program across the finish line.

FDA / EMA ISS / ISE Reviewer Response Audit Readiness
04

Data Monitoring & Advanced Analytics

Interim reviews, Bayesian methods, real-world evidence, and machine learning-assisted exploratory analysis.

Interim Analysis Bayesian RWE ML-Assisted
05

Study Design & Protocol

Strategic protocol development and endpoint selection optimized for regulatory success and operational feasibility.

Protocol Optimization Endpoint Selection Risk Mitigation
06

Consulting & Strategic Support

High-level strategic partnership for programs that need experienced biostatistical thinking early and often.

Program Strategy Pre-IND Vendor Oversight
Our Process

How we work
with you.

A clear, collaborative process from first conversation to final delivery.

1

Initial Consultation

Understand your program goals, timeline, and regulatory context

2

Scope Definition

Detailed scoping of statistical tasks, deliverables, and responsibilities

3

Proposal & Timeline

Transparent proposal with clear milestones and fixed or flexible pricing

4

Execution

Senior-led execution with direct communication throughout

5

QC & Delivery

Independent validation and thorough QC before every deliverable

6

Ongoing Support

Continued support through review cycles, queries, and subsequent submissions

Engagement Model

Flexible partnerships
for every stage.

We adapt to where you are in development and what you need — not the other way around.

Quality & Compliance

Standards that
regulators trust.

Every deliverable is built to the exacting standards required for global regulatory submissions.

ICH E9

Statistical Principles for Clinical Trials

All statistical analysis plans and methodology align with ICH E9 guidance, including the E9(R1) addendum on estimands.

CDISC

SDTM & ADaM Dataset Standards

All datasets conform to CDISC standards for electronic submission, including full reviewer's guide documentation.

21 CFR

Part 11 Compliance

Secure environments with controlled access, audit trails, and electronic records management in full compliance with 21 CFR Part 11.

Our Quality Control Process

Every output passes through multiple independent validation layers before delivery — no exceptions.

Double programming validation for all datasets and TLFs
Independent statistical review of all SAPs and analyses
Standardized SOPs across all project types and phases
Secure data environments with global compliance standards
Senior biostatistician review on every deliverable
Who We Serve

Built for the life
sciences industry.

From early-stage biotech to established pharma, we tailor our approach to the unique needs of each client and study type.

Biotech Startups

IND-enabling studies, protocol design, and regulatory strategy for companies with lean internal teams

Mid-Size Pharma

Phase II/III trial support and submission packages for established programs seeking flexible specialist capacity

Academic & Investigator Trials

Rigorous study design and statistical analysis for investigator-initiated and academic-sponsored research

Medical Device Companies

Device-specific statistical methodology and regulatory submission support aligned with FDA and global standards

"
From study start-up through reporting, all discussions on statistical strategy and best practice were conducted with a clear understanding of the sponsor's objectives for the trial.
Director, Clinical Operations · Biotechnology Company
Get In Touch

Start your project
with us today.

Let's accelerate your clinical program with precision. Our team is ready to discuss your statistical needs — whether you're designing a first-in-human study or preparing for your NDA submission.

Email info@trialiahealth.com
Phone +1-XXX-XXX-XXXX
Response Within 1 business day